Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
Identifieur interne : 007416 ( Main/Exploration ); précédent : 007415; suivant : 007417Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
Auteurs : Rachel M. Freathy [Royaume-Uni] ; Dennis O. Mook-Kanamori [Pays-Bas] ; Ulla Sovio [Royaume-Uni] ; Inga Prokopenko [Royaume-Uni] ; Nicholas J. Timpson [Royaume-Uni] ; Diane J. Berry [Royaume-Uni] ; Nicole M. Warrington [Australie] ; Elisabeth Widen [Finlande] ; Jouke Jan Hottenga [Pays-Bas] ; Marika Kaakinen [Finlande] ; Leslie A. Lange [États-Unis] ; Jonathan P. Bradfield [États-Unis] ; Marjan Kerkhof [Pays-Bas] ; Julie A. Marsh [Australie] ; Reedik M Gi [Royaume-Uni] ; Chih-Mei Chen [Allemagne] ; Helen N. Lyon [États-Unis] ; Mirna Kirin [Royaume-Uni] ; Linda S. Adair [États-Unis] ; Yurii S. Aulchenko [Pays-Bas] ; Amanda J. Bennett [Royaume-Uni] ; Judith B. Borja [Philippines] ; Nabila Bouatia-Naji [France] ; Pimphen Charoen [Royaume-Uni] ; Lachlan J. M. Coin [Royaume-Uni] ; Diana L. Cousminer [Finlande] ; Eco J. C. De Geus [Pays-Bas] ; Panos Deloukas ; Paul Elliott [Royaume-Uni] ; David M. Evans [Royaume-Uni] ; Philippe Froguel [France] ; Beate Glaser [Royaume-Uni] ; Christopher J. Groves [Royaume-Uni] ; Anna-Liisa Hartikainen ; Neelam Hassanali [Royaume-Uni] ; Joel N. Hirschhorn [États-Unis] ; Albert Hofman [Pays-Bas] ; Jeff M. P. Holly ; Elina Hyppönen [Royaume-Uni] ; Stavroula Kanoni ; Bridget A. Knight ; Jaana Laitinen ; Cecilia M. Lindgren [Royaume-Uni] ; Wendy L. Mcardle ; Paul F. O'Reilly [Royaume-Uni] ; Craig E. Pennell ; Dirkje S. Postma ; Anneli Pouta ; Adaikalavan Ramasamy [Royaume-Uni] ; Nigel W. Rayner [Royaume-Uni] ; Susan M. Ring ; Fernando Rivadeneira [Pays-Bas] ; Beverley M. Shields ; David P. Strachan ; Ida Surakka [Finlande] ; Anja Taanilal [Pays-Bas] ; Carla Tiesler [Allemagne]Source :
- Nature genetics [ 1061-4036 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEER1 and CCNL1 (P = 2 x 10-35) and rs9883204 in ADCY5 (P = 7 x 10-15) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes1, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes2,3 has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight-lowering alleles were, on average, 113 g (95% CI 89-137 g) lighter at birth than the 24% with zero or one alleles (Ptrend = 7 x 10-30). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy4.
Affiliations:
- Allemagne, Australie, Finlande, France, Pays-Bas, Philippines, Royaume-Uni, États-Unis
- Angleterre, Bavière, Caroline du Nord, District de Haute-Bavière, Grand Londres, Groningue (province), Hauts-de-France, Hollande-Méridionale, Hollande-Septentrionale, Massachusetts, Nord-Pas-de-Calais, Oxfordshire, Pennsylvanie, Uusimaa, Écosse
- Amsterdam, Groningue, Helsinki, Lille, Londres, Munich, Oxford, Rotterdam, Édimbourg
- Université Louis-et-Maximilien de Munich, Université d'Helsinki, Université d'Oxford, Université d'Édimbourg
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Mook-Kanamori</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Pediatrics, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ><sZ>52 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>The Generation R Study, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter</s1><s2>Exeter</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Exeter</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J." last="Timpson">Nicholas J. Timpson</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House</s1><s2>Bristol</s2><s3>GBR</s3><sZ>5 aut.</sZ><sZ>30 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Berry, Diane J" sort="Berry, Diane J" uniqKey="Berry D" first="Diane J." last="Berry">Diane J. Berry</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health</s1><s2>London</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Warrington, Nicole M" sort="Warrington, Nicole M" uniqKey="Warrington N" first="Nicole M." last="Warrington">Nicole M. Warrington</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia</s1><s2>Perth, Western Australia</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Perth, Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>8 aut.</sZ><sZ>26 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke Jan" last="Hottenga">Jouke Jan Hottenga</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Department of Biological Psychology, Vrije Universiteit Amsterdam</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>9 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Institute of Health Sciences, University of Oulu</s1><s2>Oulu</s2><s3>FIN</s3><sZ>10 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Biocenter Oulu, University of Oulu</s1><s2>Oulu</s2><s3>FIN</s3><sZ>10 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A." last="Lange">Leslie A. Lange</name><affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Genetics, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Bradfield, Jonathan P" sort="Bradfield, Jonathan P" uniqKey="Bradfield J" first="Jonathan P." last="Bradfield">Jonathan P. Bradfield</name><affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Center for Applied Genomics, The Children's Hospital of Philadelphia</s1><s2>Pennsylvania</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Kerkhof, Marjan" sort="Kerkhof, Marjan" uniqKey="Kerkhof M" first="Marjan" last="Kerkhof">Marjan Kerkhof</name><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Department of Epidemiology, University Medical Center Groningen, University of Groningen</s1><s2>Groningen</s2><s3>NLD</s3><sZ>13 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Marsh, Julie A" sort="Marsh, Julie A" uniqKey="Marsh J" first="Julie A." last="Marsh">Julie A. Marsh</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia</s1><s2>Perth, Western Australia</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Perth, Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Wellcome Trust Centre for Human Genetics, University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>15 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Chen, Chih Mei" sort="Chen, Chih Mei" uniqKey="Chen C" first="Chih-Mei" last="Chen">Chih-Mei Chen</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology</s1><s2>Neuherberg</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>57 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Institute of Epidemiology</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="19"><s1>Ludwig-Maximilians University of Munich, Dr. von Hauner Children's Hospital</s1><s2>Munich</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>57 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Lyon, Helen N" sort="Lyon, Helen N" uniqKey="Lyon H" first="Helen N." last="Lyon">Helen N. Lyon</name><affiliation wicri:level="2"><inist:fA14 i1="20"><s1>Division of Genetics, Program in Genomics, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="21"><s1>Department of Pediatrics, Harvard Medical School</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kirin, Mirna" sort="Kirin, Mirna" uniqKey="Kirin M" first="Mirna" last="Kirin">Mirna Kirin</name><affiliation wicri:level="4"><inist:fA14 i1="22"><s1>Centre for Population Health Sciences, University of Edinburgh</s1><s2>Edinburgh, Scotland</s2><s3>GBR</s3><sZ>18 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Adair, Linda S" sort="Adair, Linda S" uniqKey="Adair L" first="Linda S." last="Adair">Linda S. Adair</name><affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Department of Nutrition, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Aulchenko, Yurii S" sort="Aulchenko, Yurii S" uniqKey="Aulchenko Y" first="Yurii S." last="Aulchenko">Yurii S. Aulchenko</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ><sZ>52 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Bennett, Amanda J" sort="Bennett, Amanda J" uniqKey="Bennett A" first="Amanda J." last="Bennett">Amanda J. Bennett</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Borja, Judith B" sort="Borja, Judith B" uniqKey="Borja J" first="Judith B." last="Borja">Judith B. Borja</name><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Office of Population Studies Foundation, University of San Carlos</s1><s2>Cebu City</s2><s3>PHL</s3><sZ>22 aut.</sZ></inist:fA14><country>Philippines</country><wicri:noRegion>Cebu City</wicri:noRegion></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Centre<sub> </sub>National de la Recherche Scientifique, UMR 8199, Institute of Biology, Pasteur Institute of Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>23 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Coin, Lachlan J M" sort="Coin, Lachlan J M" uniqKey="Coin L" first="Lachlan J. M." last="Coin">Lachlan J. M. Coin</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Cousminer, Diana L" sort="Cousminer, Diana L" uniqKey="Cousminer D" first="Diana L." last="Cousminer">Diana L. Cousminer</name><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>8 aut.</sZ><sZ>26 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Department of Biological Psychology, Vrije Universiteit Amsterdam</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>9 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House</s1><s2>Bristol</s2><s3>GBR</s3><sZ>5 aut.</sZ><sZ>30 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Centre<sub> </sub>National de la Recherche Scientifique, UMR 8199, Institute of Biology, Pasteur Institute of Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>23 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Glaser, Beate" sort="Glaser, Beate" uniqKey="Glaser B" first="Beate" last="Glaser">Beate Glaser</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House</s1><s2>Bristol</s2><s3>GBR</s3><sZ>5 aut.</sZ><sZ>30 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Groves, Christopher J" sort="Groves, Christopher J" uniqKey="Groves C" first="Christopher J." last="Groves">Christopher J. Groves</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name></author><author><name sortKey="Hassanali, Neelam" sort="Hassanali, Neelam" uniqKey="Hassanali N" first="Neelam" last="Hassanali">Neelam Hassanali</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name><affiliation wicri:level="2"><inist:fA14 i1="20"><s1>Division of Genetics, Program in Genomics, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ><sZ>52 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Holly, Jeff M P" sort="Holly, Jeff M P" uniqKey="Holly J" first="Jeff M. P." last="Holly">Jeff M. P. Holly</name></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health</s1><s2>London</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name></author><author><name sortKey="Knight, Bridget A" sort="Knight, Bridget A" uniqKey="Knight B" first="Bridget A." last="Knight">Bridget A. Knight</name></author><author><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name></author><author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M." last="Lindgren">Cecilia M. Lindgren</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Wellcome Trust Centre for Human Genetics, University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>15 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name></author><author><name sortKey="O Reilly, Paul F" sort="O Reilly, Paul F" uniqKey="O Reilly P" first="Paul F." last="O'Reilly">Paul F. O'Reilly</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E." last="Pennell">Craig E. Pennell</name></author><author><name sortKey="Postma, Dirkje S" sort="Postma, Dirkje S" uniqKey="Postma D" first="Dirkje S." last="Postma">Dirkje S. Postma</name></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name></author><author><name sortKey="Ramasamy, Adaikalavan" sort="Ramasamy, Adaikalavan" uniqKey="Ramasamy A" first="Adaikalavan" last="Ramasamy">Adaikalavan Ramasamy</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W." last="Rayner">Nigel W. Rayner</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Wellcome Trust Centre for Human Genetics, University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>15 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ><sZ>52 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Shields, Beverley M" sort="Shields, Beverley M" uniqKey="Shields B" first="Beverley M." last="Shields">Beverley M. Shields</name></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name></author><author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>8 aut.</sZ><sZ>26 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author><author><name sortKey="Taanilal, Anja" sort="Taanilal, Anja" uniqKey="Taanilal A" first="Anja" last="Taanilal">Anja Taanilal</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ><sZ>52 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Tiesler, Carla" sort="Tiesler, Carla" uniqKey="Tiesler C" first="Carla" last="Tiesler">Carla Tiesler</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology</s1><s2>Neuherberg</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>57 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Institute of Epidemiology</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="19"><s1>Ludwig-Maximilians University of Munich, Dr. von Hauner Children's Hospital</s1><s2>Munich</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>57 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0400434</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 10-0400434 INIST</idno><idno type="RBID">Pascal:10-0400434</idno><idno type="wicri:Area/PascalFrancis/Corpus">002427</idno><idno type="wicri:Area/PascalFrancis/Curation">003B61</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001E84</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001E84</idno><idno type="wicri:doubleKey">1061-4036:2010:Freathy R:variants:in:adcy</idno><idno type="wicri:Area/Main/Merge">007952</idno><idno type="wicri:Area/Main/Curation">007416</idno><idno type="wicri:Area/Main/Exploration">007416</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight</title><author><name sortKey="Freathy, Rachel M" sort="Freathy, Rachel M" uniqKey="Freathy R" first="Rachel M." last="Freathy">Rachel M. Freathy</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter</s1><s2>Exeter</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Exeter</wicri:noRegion></affiliation></author><author><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O." last="Mook-Kanamori">Dennis O. Mook-Kanamori</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Pediatrics, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ><sZ>52 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>The Generation R Study, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter</s1><s2>Exeter</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Exeter</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J." last="Timpson">Nicholas J. Timpson</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House</s1><s2>Bristol</s2><s3>GBR</s3><sZ>5 aut.</sZ><sZ>30 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Berry, Diane J" sort="Berry, Diane J" uniqKey="Berry D" first="Diane J." last="Berry">Diane J. Berry</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health</s1><s2>London</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Warrington, Nicole M" sort="Warrington, Nicole M" uniqKey="Warrington N" first="Nicole M." last="Warrington">Nicole M. Warrington</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia</s1><s2>Perth, Western Australia</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Perth, Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>8 aut.</sZ><sZ>26 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke Jan" last="Hottenga">Jouke Jan Hottenga</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Department of Biological Psychology, Vrije Universiteit Amsterdam</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>9 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Institute of Health Sciences, University of Oulu</s1><s2>Oulu</s2><s3>FIN</s3><sZ>10 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Oulu</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Biocenter Oulu, University of Oulu</s1><s2>Oulu</s2><s3>FIN</s3><sZ>10 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A." last="Lange">Leslie A. Lange</name><affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Genetics, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Bradfield, Jonathan P" sort="Bradfield, Jonathan P" uniqKey="Bradfield J" first="Jonathan P." last="Bradfield">Jonathan P. Bradfield</name><affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Center for Applied Genomics, The Children's Hospital of Philadelphia</s1><s2>Pennsylvania</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Kerkhof, Marjan" sort="Kerkhof, Marjan" uniqKey="Kerkhof M" first="Marjan" last="Kerkhof">Marjan Kerkhof</name><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Department of Epidemiology, University Medical Center Groningen, University of Groningen</s1><s2>Groningen</s2><s3>NLD</s3><sZ>13 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Marsh, Julie A" sort="Marsh, Julie A" uniqKey="Marsh J" first="Julie A." last="Marsh">Julie A. Marsh</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia</s1><s2>Perth, Western Australia</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Perth, Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Wellcome Trust Centre for Human Genetics, University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>15 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Chen, Chih Mei" sort="Chen, Chih Mei" uniqKey="Chen C" first="Chih-Mei" last="Chen">Chih-Mei Chen</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology</s1><s2>Neuherberg</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>57 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Institute of Epidemiology</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="19"><s1>Ludwig-Maximilians University of Munich, Dr. von Hauner Children's Hospital</s1><s2>Munich</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>57 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Lyon, Helen N" sort="Lyon, Helen N" uniqKey="Lyon H" first="Helen N." last="Lyon">Helen N. Lyon</name><affiliation wicri:level="2"><inist:fA14 i1="20"><s1>Division of Genetics, Program in Genomics, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="21"><s1>Department of Pediatrics, Harvard Medical School</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kirin, Mirna" sort="Kirin, Mirna" uniqKey="Kirin M" first="Mirna" last="Kirin">Mirna Kirin</name><affiliation wicri:level="4"><inist:fA14 i1="22"><s1>Centre for Population Health Sciences, University of Edinburgh</s1><s2>Edinburgh, Scotland</s2><s3>GBR</s3><sZ>18 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Adair, Linda S" sort="Adair, Linda S" uniqKey="Adair L" first="Linda S." last="Adair">Linda S. Adair</name><affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Department of Nutrition, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Aulchenko, Yurii S" sort="Aulchenko, Yurii S" uniqKey="Aulchenko Y" first="Yurii S." last="Aulchenko">Yurii S. Aulchenko</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ><sZ>52 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Bennett, Amanda J" sort="Bennett, Amanda J" uniqKey="Bennett A" first="Amanda J." last="Bennett">Amanda J. Bennett</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Borja, Judith B" sort="Borja, Judith B" uniqKey="Borja J" first="Judith B." last="Borja">Judith B. Borja</name><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Office of Population Studies Foundation, University of San Carlos</s1><s2>Cebu City</s2><s3>PHL</s3><sZ>22 aut.</sZ></inist:fA14><country>Philippines</country><wicri:noRegion>Cebu City</wicri:noRegion></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Centre<sub> </sub>National de la Recherche Scientifique, UMR 8199, Institute of Biology, Pasteur Institute of Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>23 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Coin, Lachlan J M" sort="Coin, Lachlan J M" uniqKey="Coin L" first="Lachlan J. M." last="Coin">Lachlan J. M. Coin</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Cousminer, Diana L" sort="Cousminer, Diana L" uniqKey="Cousminer D" first="Diana L." last="Cousminer">Diana L. Cousminer</name><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>8 aut.</sZ><sZ>26 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Department of Biological Psychology, Vrije Universiteit Amsterdam</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>9 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House</s1><s2>Bristol</s2><s3>GBR</s3><sZ>5 aut.</sZ><sZ>30 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Centre<sub> </sub>National de la Recherche Scientifique, UMR 8199, Institute of Biology, Pasteur Institute of Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>23 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Glaser, Beate" sort="Glaser, Beate" uniqKey="Glaser B" first="Beate" last="Glaser">Beate Glaser</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House</s1><s2>Bristol</s2><s3>GBR</s3><sZ>5 aut.</sZ><sZ>30 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Groves, Christopher J" sort="Groves, Christopher J" uniqKey="Groves C" first="Christopher J." last="Groves">Christopher J. Groves</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name></author><author><name sortKey="Hassanali, Neelam" sort="Hassanali, Neelam" uniqKey="Hassanali N" first="Neelam" last="Hassanali">Neelam Hassanali</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name><affiliation wicri:level="2"><inist:fA14 i1="20"><s1>Division of Genetics, Program in Genomics, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ><sZ>52 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Holly, Jeff M P" sort="Holly, Jeff M P" uniqKey="Holly J" first="Jeff M. P." last="Holly">Jeff M. P. Holly</name></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health</s1><s2>London</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name></author><author><name sortKey="Knight, Bridget A" sort="Knight, Bridget A" uniqKey="Knight B" first="Bridget A." last="Knight">Bridget A. Knight</name></author><author><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name></author><author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M." last="Lindgren">Cecilia M. Lindgren</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Wellcome Trust Centre for Human Genetics, University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>15 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name></author><author><name sortKey="O Reilly, Paul F" sort="O Reilly, Paul F" uniqKey="O Reilly P" first="Paul F." last="O'Reilly">Paul F. O'Reilly</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E." last="Pennell">Craig E. Pennell</name></author><author><name sortKey="Postma, Dirkje S" sort="Postma, Dirkje S" uniqKey="Postma D" first="Dirkje S." last="Postma">Dirkje S. Postma</name></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name></author><author><name sortKey="Ramasamy, Adaikalavan" sort="Ramasamy, Adaikalavan" uniqKey="Ramasamy A" first="Adaikalavan" last="Ramasamy">Adaikalavan Ramasamy</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>29 aut.</sZ><sZ>45 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W." last="Rayner">Nigel W. Rayner</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1><s3>GBR</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>33 aut.</sZ><sZ>35 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Wellcome Trust Centre for Human Genetics, University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>15 aut.</sZ><sZ>43 aut.</sZ><sZ>50 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ><sZ>52 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Shields, Beverley M" sort="Shields, Beverley M" uniqKey="Shields B" first="Beverley M." last="Shields">Beverley M. Shields</name></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name></author><author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>8 aut.</sZ><sZ>26 aut.</sZ><sZ>55 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author><author><name sortKey="Taanilal, Anja" sort="Taanilal, Anja" uniqKey="Taanilal A" first="Anja" last="Taanilal">Anja Taanilal</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ><sZ>37 aut.</sZ><sZ>52 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Tiesler, Carla" sort="Tiesler, Carla" uniqKey="Tiesler C" first="Carla" last="Tiesler">Carla Tiesler</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Helmholtz Zentrum Muenchen, German Research Centre for Environmental Health, Institute of Epidemiology</s1><s2>Neuherberg</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>57 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Institute of Epidemiology</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="19"><s1>Ludwig-Maximilians University of Munich, Dr. von Hauner Children's Hospital</s1><s2>Munich</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>57 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author></analytic><series><title level="j" type="main">Nature genetics</title><title level="j" type="abbreviated">Nat. genet.</title><idno type="ISSN">1061-4036</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Nature genetics</title><title level="j" type="abbreviated">Nat. genet.</title><idno type="ISSN">1061-4036</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Birth weight</term><term>Fetus</term><term>Growth</term><term>Variant</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Variant</term><term>Foetus</term><term>Croissance</term><term>Poids naissance</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEER1 and CCNL1 (P = 2 x 10<sup>-35</sup>) and rs9883204 in ADCY5 (P = 7 x 10<sup>-15</sup>) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes<sup>1</sup>, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes<sup>2,3</sup> has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight-lowering alleles were, on average, 113 g (95% CI 89-137 g) lighter at birth than the 24% with zero or one alleles (P<sub>trend</sub> = 7 x 10<sup>-30</sup>). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy<sup>4</sup>.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Finlande</li><li>France</li><li>Pays-Bas</li><li>Philippines</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bavière</li><li>Caroline du Nord</li><li>District de Haute-Bavière</li><li>Grand Londres</li><li>Groningue (province)</li><li>Hauts-de-France</li><li>Hollande-Méridionale</li><li>Hollande-Septentrionale</li><li>Massachusetts</li><li>Nord-Pas-de-Calais</li><li>Oxfordshire</li><li>Pennsylvanie</li><li>Uusimaa</li><li>Écosse</li></region><settlement><li>Amsterdam</li><li>Groningue</li><li>Helsinki</li><li>Lille</li><li>Londres</li><li>Munich</li><li>Oxford</li><li>Rotterdam</li><li>Édimbourg</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li><li>Université d'Helsinki</li><li>Université d'Oxford</li><li>Université d'Édimbourg</li></orgName></list><tree><noCountry><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><name sortKey="Holly, Jeff M P" sort="Holly, Jeff M P" uniqKey="Holly J" first="Jeff M. P." last="Holly">Jeff M. P. Holly</name><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name><name sortKey="Knight, Bridget A" sort="Knight, Bridget A" uniqKey="Knight B" first="Bridget A." last="Knight">Bridget A. Knight</name><name sortKey="Laitinen, Jaana" sort="Laitinen, Jaana" uniqKey="Laitinen J" first="Jaana" last="Laitinen">Jaana Laitinen</name><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E." last="Pennell">Craig E. Pennell</name><name sortKey="Postma, Dirkje S" sort="Postma, Dirkje S" uniqKey="Postma D" first="Dirkje S." last="Postma">Dirkje S. Postma</name><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name><name sortKey="Shields, Beverley M" sort="Shields, Beverley M" uniqKey="Shields B" first="Beverley M." last="Shields">Beverley M. Shields</name><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Freathy, Rachel M" sort="Freathy, Rachel M" uniqKey="Freathy R" first="Rachel M." last="Freathy">Rachel M. Freathy</name></noRegion><name sortKey="Bennett, Amanda J" sort="Bennett, Amanda J" uniqKey="Bennett A" first="Amanda J." last="Bennett">Amanda J. Bennett</name><name sortKey="Berry, Diane J" sort="Berry, Diane J" uniqKey="Berry D" first="Diane J." last="Berry">Diane J. Berry</name><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name><name sortKey="Coin, Lachlan J M" sort="Coin, Lachlan J M" uniqKey="Coin L" first="Lachlan J. M." last="Coin">Lachlan J. M. Coin</name><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name><name sortKey="Glaser, Beate" sort="Glaser, Beate" uniqKey="Glaser B" first="Beate" last="Glaser">Beate Glaser</name><name sortKey="Groves, Christopher J" sort="Groves, Christopher J" uniqKey="Groves C" first="Christopher J." last="Groves">Christopher J. Groves</name><name sortKey="Hassanali, Neelam" sort="Hassanali, Neelam" uniqKey="Hassanali N" first="Neelam" last="Hassanali">Neelam Hassanali</name><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><name sortKey="Kirin, Mirna" sort="Kirin, Mirna" uniqKey="Kirin M" first="Mirna" last="Kirin">Mirna Kirin</name><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M." last="Lindgren">Cecilia M. Lindgren</name><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M." last="Lindgren">Cecilia M. Lindgren</name><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><name sortKey="O Reilly, Paul F" sort="O Reilly, Paul F" uniqKey="O Reilly P" first="Paul F." last="O'Reilly">Paul F. O'Reilly</name><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><name sortKey="Ramasamy, Adaikalavan" sort="Ramasamy, Adaikalavan" uniqKey="Ramasamy A" first="Adaikalavan" last="Ramasamy">Adaikalavan Ramasamy</name><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W." last="Rayner">Nigel W. Rayner</name><name sortKey="Rayner, Nigel W" sort="Rayner, Nigel W" uniqKey="Rayner N" first="Nigel W." last="Rayner">Nigel W. Rayner</name><name sortKey="Sovio, Ulla" sort="Sovio, Ulla" uniqKey="Sovio U" first="Ulla" last="Sovio">Ulla Sovio</name><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J." last="Timpson">Nicholas J. Timpson</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O." last="Mook-Kanamori">Dennis O. Mook-Kanamori</name></region><name sortKey="Aulchenko, Yurii S" sort="Aulchenko, Yurii S" uniqKey="Aulchenko Y" first="Yurii S." last="Aulchenko">Yurii S. Aulchenko</name><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke Jan" last="Hottenga">Jouke Jan Hottenga</name><name sortKey="Kerkhof, Marjan" sort="Kerkhof, Marjan" uniqKey="Kerkhof M" first="Marjan" last="Kerkhof">Marjan Kerkhof</name><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O." last="Mook-Kanamori">Dennis O. Mook-Kanamori</name><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O." last="Mook-Kanamori">Dennis O. Mook-Kanamori</name><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><name sortKey="Taanilal, Anja" sort="Taanilal, Anja" uniqKey="Taanilal A" first="Anja" last="Taanilal">Anja Taanilal</name></country><country name="Australie"><noRegion><name sortKey="Warrington, Nicole M" sort="Warrington, Nicole M" uniqKey="Warrington N" first="Nicole M." last="Warrington">Nicole M. Warrington</name></noRegion><name sortKey="Marsh, Julie A" sort="Marsh, Julie A" uniqKey="Marsh J" first="Julie A." last="Marsh">Julie A. Marsh</name></country><country name="Finlande"><region name="Uusimaa"><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name></region><name sortKey="Cousminer, Diana L" sort="Cousminer, Diana L" uniqKey="Cousminer D" first="Diana L." last="Cousminer">Diana L. Cousminer</name><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name><name sortKey="Kaakinen, Marika" sort="Kaakinen, Marika" uniqKey="Kaakinen M" first="Marika" last="Kaakinen">Marika Kaakinen</name><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name></country><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A." last="Lange">Leslie A. Lange</name></region><name sortKey="Adair, Linda S" sort="Adair, Linda S" uniqKey="Adair L" first="Linda S." last="Adair">Linda S. Adair</name><name sortKey="Bradfield, Jonathan P" sort="Bradfield, Jonathan P" uniqKey="Bradfield J" first="Jonathan P." last="Bradfield">Jonathan P. Bradfield</name><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name><name sortKey="Lyon, Helen N" sort="Lyon, Helen N" uniqKey="Lyon H" first="Helen N." last="Lyon">Helen N. Lyon</name><name sortKey="Lyon, Helen N" sort="Lyon, Helen N" uniqKey="Lyon H" first="Helen N." last="Lyon">Helen N. Lyon</name></country><country name="Allemagne"><noRegion><name sortKey="Chen, Chih Mei" sort="Chen, Chih Mei" uniqKey="Chen C" first="Chih-Mei" last="Chen">Chih-Mei Chen</name></noRegion><name sortKey="Chen, Chih Mei" sort="Chen, Chih Mei" uniqKey="Chen C" first="Chih-Mei" last="Chen">Chih-Mei Chen</name><name sortKey="Tiesler, Carla" sort="Tiesler, Carla" uniqKey="Tiesler C" first="Carla" last="Tiesler">Carla Tiesler</name><name sortKey="Tiesler, Carla" sort="Tiesler, Carla" uniqKey="Tiesler C" first="Carla" last="Tiesler">Carla Tiesler</name></country><country name="Philippines"><noRegion><name sortKey="Borja, Judith B" sort="Borja, Judith B" uniqKey="Borja J" first="Judith B." last="Borja">Judith B. Borja</name></noRegion></country><country name="France"><region name="Hauts-de-France"><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name></region><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
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